Impact of 2?-Fucosyllactose on Gut Microbiota Composition in Adults with Chronic Gastrointestinal Conditions: Batch Culture Fermentation Model and Pilot Clinical Trial Findings
نویسندگان
چکیده
Intestinal dysbiosis has been described in patients with certain gastrointestinal conditions including irritable bowel syndrome (IBS) and ulcerative colitis. 2?-fucosyllactose (2?-FL), a prebiotic human milk oligosaccharide, is considered bifidogenic butyrogenic. To assess effects of 2?-FL, alone or combination probiotic strains (potential synbiotics), vitro experiments were conducted on stool from healthy, IBS, colitis adult donors. In anaerobic batch culture fermenters, Bifidobacterium Eubacterium rectale-Clostridium coccoides counts, short-chain fatty acids (SCFAs) butyrate increased during fermentation 2?-FL some the 2?-FL/probiotic combinations. subsequent open-label pilot trial, effect 2?-FL-containing nutritional formula was evaluated twelve adults IBS Gastrointestinal Quality Life Index (GIQLI) total symptoms domain scores, counts Faecalibacterium prausnitzii, SCFAs butyrate, after six weeks intervention. Consistent documented demonstrated butyrogenic samples. Consumption by associated improvements intra- extra-intestinal symptoms, effects.
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ژورنال
عنوان ژورنال: Nutrients
سال: 2021
ISSN: ['2072-6643']
DOI: https://doi.org/10.3390/nu13030938